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Phenocarta

Previously known as Neurocarta

Go to Phenocarta tool.

Phenocarta is a knowledgebase that consolidates information on genes and phenotypes across multiple resources and allows tracking and exploring of the associations. The system enables automatic and manual curation of evidence supporting each association, as well as user-enabled entry of their own annotations. Phenotypes are recorded using controlled vocabularies such as the Disease Ontology to facilitate computational inference and linking to external data sources. The gene-to-phenotype associations are filtered by stringent criteria to focus on the annotations most likely to be relevant. Phenocarta is constantly growing and currently holds more than 40,000 lines of evidence linking over 9,000 genes to 2,000 different phenotypes. In addition to the data coming from external resources, Phenocarta includes a set of in-house manually curated annotations of neurodevelopmental disorders.

Phenocarta is a one-stop shop for researchers looking for candidate genes for any disorder of interest. In Phenocarta, they can review the evidence linking genes to phenotypes and filter out the evidence they’re not interested in. In addition, researchers can enter their own annotations from their experiments and analyze them in the context of existing public annotations.

Portales-Casamar, E., et al., Neurocarta: aggregating and sharing disease-gene relations for the neurosciences. BMC Genomics. 2013 Feb 26;14(1):129. (Link)